The Prophecies. In this book he compiled his collection of major, long-term predictions. The first installment was published in 1555. The second, with 289 further prophetic verses, was printed in 1557. The third edition, with three hundred new quatrains, was reportedly printed in 1558, but nowadays only survives as part of the omnibus edition that was published after his death in 1568. This version contains one unrhymed and 941 rhymed quatrains, grouped into nine sets of 100 and one of 42, called "Centuries".

Given printing practices at the time (which included type-setting from dictation), no two editions turned out to be identical, and it is relatively rare to find even two copies that are exactly the same. Certainly there is no warrant for assuming – as would-be "code-breakers" are prone to do – that either the spellings or the punctuation of any edition are Nostradamus' originals.

The Almanacs. By far the most popular of his works, these were published annually from 1550 until his death. He often published two or three in a year, entitled either Almanachs (detailed predictions), Prognostications or Presages (more generalized predictions).

Nostradamus was not only a diviner, but a professional healer, too. It is known that he wrote at least two books on medical science. One was an alleged "translation" of Galen, and in his so-called Traité des fardemens (basically a medical cookbook containing, once again, materials borrowed mainly from others), he included a description of the methods he used to treat the plague — none of which, not even the bloodletting, apparently worked. The same book also describes the preparation of cosmetics.

A manuscript normally known as the Orus Apollo also exists in the Lyon municipal library, where upwards of 2,000 original documents relating to Nostradamus are stored under the aegis of Michel Chomarat. It is a purported translation of an ancient Greek work on Egyptian hieroglyphs based on later Latin versions, all of them unfortunately ignorant of the true meanings of the ancient Egyptian script, which was not correctly deciphered until the advent of Champollion in the 19th century.

Since his death only the Prophecies have continued to be popular, but in this case they have been quite extraordinarily so. Over two hundred editions of them have appeared in that time, together with over 2000 commentaries. Their popularity seems to be partly due to the fact that their vagueness and lack of dating make it easy to quote them selectively after every major dramatic event and retrospectively claim them as "hits"